Friday, February 4, 2011

Chronic Wasting Disease Found in Minnesota Wild Deer

Chronic Wasting Disease Found in Minnesota Wild Deer: "- Sent using Google Toolbar"

Wandering About Nature Today
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2 comments:

  1. hshieldsFebruary 5, 2011 at 8:09 PM

    "Substantial evidence suggests that prions can persist in the environment, implicating it as a potential prion reservoir and transmission vehicle. CWD- positive animals can contribute to environmental prion load via biological materials including saliva, blood, urine and feces, shedding several times their body weight in possibly infectious excreta in their lifetime, as well as through decomposing carcasses "
    http://chronic-wasting-disease.blogspot.com/2009/12/south-dakotas-chronic-wasting-disease.html


    "We also detected PrP(CWD) in one of two environmental water samples from a CWD endemic area collected at a time of increased water runoff from melting winter snow pack, as well as in water samples obtained concurrently from the flocculation stage of water processing by the municipal water treatment facility. "
    http://www.aphis.usda.gov/wildlife_damage/nwrc/publications/09pubs/nichols091.pdf


    Dr. Glen Telling - Prions in deer muscle tissue http://www.newscientist.com/article/dn8638-prion-disease-found-lurking-in-deer-muscle.html
    "But Telling's lab has now shown that diseased prions can reside in muscle of deer infected with CWD, by using transgenic mice. "

    "The team replaced the gene for the normal mouse version of the prion protein with the normal gene from deer, so the mice made the normal, healthy deer protein. They then injected the mouse brains with tissue from infected deer. Twelve to 18 months later, the mice developed encephalopathy.
    Tissues from both the infected deers' brains and thigh muscle caused disease. Muscle took slightly longer to cause disease than brain tissue, showing it had slightly less prion."

    "Because we tested deer that were already ill," he told New Scientist, "we don't know what the distribution of prion is in animals that are still incubating the disease." Hunters have been warned by wildlife agencies not to kill and eat obviously ill animals, but an animal not yet showing signs of the disease might still carry the abnormal prion, albeit less of it."

    http://chronic-wasting-disease.blogspot.com/2011/01/generation-of-new-form-of-human-prpsc.html
    Generation of a new form of human PrPSc in vitro by inter-species transmission from cervids prions
    Marcelo A. Barria1, Glenn C. Telling2, Pierluigi Gambetti3, James A. Mastrianni4 and Claudio Soto1,*


    "Our results have far-reaching implications for human health, since they indicate that cervid PrPSc can trigger the conversion of human PrPC into PrPSc, suggesting that CWD might be infectious to humans. Interestingly our findings suggest that unstable strains from CWD affected animals might not be a problem for humans, but upon strain stabilization by successive passages in the wild, this disease might become progressively more transmissible to man."
    "

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  2. TheNaturalistFebruary 5, 2011 at 9:02 PM

    hshields-Very interesting developments. I lived in the UK in '97-98 just about the time 'Mad Cow' disease was at it's public flux. I think it's interesting that the more research that is obtained and understood-the longer we discover we have been co-existing with certain organisms and pathogens.How truly dangerous they can be-and their accelerated ability to adapt!

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